Sildenafil vs Tadalafil: Which ED Treatment Fits Your Routine?

The short version

Sildenafil works fast and wears off within about four to six hours. Tadalafil takes a little longer to kick in but can stay active for up to 36 hours, which is why it is often called the weekend option.

Onset and duration

• Sildenafil: 30-60 minutes to onset, 4-6 hours of effect.
• Tadalafil: 30-120 minutes to onset, up to 36 hours of effect.

Food and alcohol

Sildenafil absorption slows noticeably after a heavy or high-fat meal. Tadalafil is far less affected by food, which makes it easier to plan around dinner. Both should be kept well away from heavy drinking.

Cost per dose

Generic versions of both are inexpensive at larger pack sizes. Because tadalafil covers a longer window, many people use fewer doses per month for the same level of spontaneity.

Talk to a clinician first

Neither medicine is suitable if you take nitrates or have certain heart conditions. This article is general information, not medical advice.